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KMID : 0379119810090010025
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Korean Journal of Mycology
1981 Volume.9 No. 1 p.25 ~ p.29
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Studies on the Antitumor Components of Korean Basidiomycetes (2)
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Abstract
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To investigate antitumor components of Korean higher fungi, the carpophores of Schizophyllum commune and Auricularia auricula-judge collected in Kyeong Buk Province were extracted with hot water or 0.1N-NaOH solution. The concentrated extracts were precipitated by addition of ethanol, and the precipitates were purified by dialyzing through visking tube and polysaccharide fractions were obtained.
They were found to show antitumor activity against sarcoma 180 implanted in mice. Especially, the inhibition ratio of the extract of Auricularia adicula-judge was 90.8% in the doses of 100㎎/㎏/day for the period of ten days. The tumor in five of the eight mice was completely regressed.
The components of these aqueous extracts were found to be polysaccharide and protein. The hydrolysis of the respective polysaccharide yielded four monosaccharides. After hydrolysis of the protein fraction, 15 amino acids were identified in the respective fraction of S. commune and A. auricula-judge.
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